Tolcapone

**Semantic type:** Pharmacologic Substance

**Definition:** A benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone selectively and reversibly inhibits COMT, an enzyme that catalyzes the metabolism of biologically active catechols and their hydroxylated metabolites by transferring the methyl group of S-adenosyl-L-methionine to the phenolic group of catechol-containing substrates. When given in conjunction with a peripheral dopa decarboxylase inhibitor and levodopa, tolcapone may prevent the metabolism of levodopa to 3-methoxy-4-hydroxy- L-phenylalanine (3-OMD) in the brain and peripheral tissues leading to increased bioavailability and enhancement of delivery to the central nervous system (CNS) of levodopa.

**Synonyms:** - 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone - Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)- - TOLCAPONE - Tasmar