Cefamandole Nafate

**Semantic type:** Antibiotic|Pharmacologic Substance

**Definition:** The sodium salt form of cefamandole formyl ester. Cefamandole nafate is a pro-drug that is hydrolyzed by plasma esterases to produce cefamandole, a semi-synthetic beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

**Synonyms:** - Bergacef - CEFAMANDOLE NAFATE - Cedol - Cefam - Lilly 106223 - Mandol - Mandolsan - O-Formylcefamandole Sodium