Lidocaine Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.

**Synonyms:** - 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide Monohydrochloride - LIDOCAINE HYDROCHLORIDE - Xylocaine - Xylocaine - Xylocitin - Xylocitin - Xylotox - Xylotox