Methylprednisolone Sodium Succinate

**Semantic type:** Pharmacologic Substance

**Definition:** The sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. Methylprednisolone sodium succinate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.

**Synonyms:** - A-MethaPred - Asmacortone - Cryosolona - METHYLPREDNISOLONE SODIUM SUCCINATE - Medrate - Metypred - Prednilem - Solu Moderin - Solu-Medrol - Solu-Medrol - Solu-Medrone - Solu-Medrone