Multikinase Inhibitor AEE788

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. (NCI05)

**Synonyms:** - AEE 788 - AEE-788 - AEE-788 - AEE788