Motesanib Diphosphate

**Semantic type:** Pharmacologic Substance

**Definition:** The orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.

**Synonyms:** - 3-Pyridinecarboxamide, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-((4-pyridinylmethyl)amino)-, phosphate (1:2) - AMG 706 - AMG 706 - AMG-706 - AMG706 - MOTESANIB DIPHOSPHATE