Cediranib Maleate

**Semantic type:** Pharmacologic Substance

**Definition:** The maleate salt of an indole ether quinazoline derivative with antineoplastic activities. Competing with adenosine triphosphate, cediranib binds to and inhibits all three vascular endothelial growth factor receptor (VEGFR-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.

**Synonyms:** - AZD2171 - AZD2171 Maleate - CEDIRANIB MALEATE - Quinazoline, 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(1-pyrrolidinyl)propoxy)- - Recentin - Recentin - cediranib maleate