Bardoxolone

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression.

**Synonyms:** - 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid - 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid - BARDOXOLONE - CDDO - CDDO - Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo- - RTA 401