Eculizumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized monoclonal antibody directed against terminal complement protein C5. Eculizumab binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory components and blocking the complement-mediated destruction of paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. (NCI05)

**Synonyms:** - ABP 959 - ABP-959 - ABP959 - Alexion - BCD 148 - BCD-148 - BCD148 - ECULIZUMAB - Eculizumab Biosimilar ABP 959 - Eculizumab Biosimilar BCD-148 - Eculizumab Biosimilar SB12 - Eculizumab-beke - Eculizumab-epys - Elizaria - Immunoglobulin, Anti-(Human Complement C5 Alpha-Chain) (Human-Mouse Monoclonal 5G1.1 Heavy Chain), Disulfide with Human-Mouse Monoclonal 5G.1.1 Light Chain, Dimer - Monoclonal antibody 5G1.1 - SB 12 - SB-12 - SB12 - Soliris - Soliris - eculizumab - h5G1.1