Lestaurtinib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3. (NCI05)

**Synonyms:** - 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)- - CEP 701 - CEP-701 - CEP-701 - CEP-701 - CEP701 - KT-5555 - LESTAURTINIB - SPM-924 - lestaurtinib