Picoplatin

**Semantic type:** Inorganic Chemical|Pharmacologic Substance

**Definition:** A new generation organic platinum analog with an extended spectrum of antineoplastic activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and transcription, and the induction of apoptosis.

**Synonyms:** - AMD473 - Cis-Amminedichloro (2-Methylpyridine) Platinum (II) - JM473 - NX-473 - PICOPLATIN - Platinum, Amminedichloro(2-methylpyridine)-, (SP-4-3)- - ZD0473 - ZD0473