Ropidoxuridine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally available 5-substituted 2-pyrimidinone-2'-deoxyribonucleoside analogue and prodrug of 5-iododeoxyuridine (IUdR), an iodinated analogue of deoxyuridine, with radiosensitizing activity. Upon oral administration, ropidoxuridine (IPdR) is efficiently converted to idoxuridine (IUdR) by a hepatic aldehyde oxidase. In turn, IUdR is incorporated into DNA during replication, thereby sensitizing cells to ionizing radiation by increasing DNA strand breaks. Compared to IUdR, ropidoxuridine is associated with a lower toxicity profile and improved anti-tumor activity.

**Synonyms:** - 2(1H)-Pyrimidinone, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-iodo- - 5-Iodo-2-pyrimidinone 2' deoxyribonucleoside - 5-Iodo-2-pyrimidinone-2'-deoxyribose - IPdR - ROPIDOXURIDINE