78 kDa Glucose-Regulated Protein

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** 78 kDa glucose-regulated protein (654 aa, ~72kDa) is encoded by the human HSPA5 gene. The protein is intracellularly localized in the endoplasmic reticulum lumen, and plays a role in the assembly of multimeric protein complexes inside the organelle. In addition, the protein is thought to function as a pro-survival protein, or an inhibitor of apoptosis.

**Synonyms:** - BiP - BiP Protein - Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein grp78 - GRP 78 Protein - GRP78 - HSPA5 - Heat Shock 70 kDa Protein 5 - Immunoglobulin Heavy Chain Binding Protein - Immunoglobulin Heavy Chain-Binding Protein