Myxoinflammatory Fibroblastic Sarcoma

**Semantic type:** Neoplastic Process

**Definition:** A low grade, locally aggressive, fibroblastic neoplasm that occurs primarily in the distal extremities. It is characterized by the presence of spindle-shaped fibroblasts, multivacuolated lipoblast-like cells, bizarre ganglion-like cells with inclusion-like nuclei, myxoid stroma formation, and a mixture of acute and chronic inflammatory cells. Distant metastases are very rare.

**Synonyms:** - Acral Myxoinflammatory Fibroblastic Sarcoma - Inflammatory Myxohyaline Tumor of the Distal Extremities with Virocyte/Reed-Sternberg-Like Cells - Inflammatory Myxoid Tumor of the Soft Parts with Bizarre Giant Cells - MIFS - Myxoinflammatory fibroblastic sarcoma (MIFS)