Giant Cell Tumor of Soft Tissue

**Semantic type:** Neoplastic Process

**Definition:** A painless, well circumscribed tumor arising in soft tissue, usually of the upper and lower extremities. Morphologically, it is characterized by a multinodular growth pattern. The cellular infiltrate is composed of mononuclear round or oval cells and multinucleated osteoclast-like giant cells, in a rich vascular stroma. It rarely metastasizes.

**Synonyms:** - GCT-ST - Giant Cell Tumor of Low Malignant Potential - Giant cell tumor of soft parts, NOS - Osteoclastoma of Soft Tissue