Aprepitant

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors.

**Synonyms:** - 5-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-1,2-dihydro-3H-1,2,4-Triazol-3-one - APREPITANT - Aponvie - CINVANTI - Emend - Emend - L-754030 - MK 0869 - MK-0869 - MK0869 - ONO-7436 - aprepitant