FOLH1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human FOLH1 wild-type allele is located in the vicinity of 11p11.2 and is approximately 62 kb in length. This allele, which encodes glutamate carboxypeptidase 2 protein, plays a role in both the uptake of folate in the intestine and the hydrolysis of N-aceylaspartylglutamate, the major neurotransmitter in the brain. This gene is overexpressed in human prostate cancer and may inhibit metastasis of this disease.

**Synonyms:** - FGCP - FOLH - Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 Gene - Folate Hydrolase 1 wt Allele - GCP2 - GCPII - GIG27 - NAALAD1 - NAALAdase - PSM - PSMA - mGCP