HDAC3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human HDAC3 wild-type allele is located within 5q31 and is approximately 16 kb in length. This allele, which encodes histone deacetylase 3 protein, plays a role in the both the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4) and the binding of transcription factor YY1. Deregulation of HDAC3 gene expression is associated with colon cancer.

**Synonyms:** - HD3 - Histone Deacetylase 3 wt Allele - RPD3 - RPD3-2