NUDT1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NUDT1 wild-type allele is located within 7p22 and is approximately 9 kb in length. This allele, which encodes oxidized purine nucleoside triphosphate hydrolase protein, is involved in the hydrolysis of 8-oxo-dGTP in the free nucleotide pool. Overexpression of the NUDT1 gene is associated with several types of cancer such as non-small-cell lung carcinomas, renal cell carcinomas and prostate cancer.

**Synonyms:** - MTH1 - MutT Human Homolog 1 Gene - Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 Gene - Nudix Hydrolase 1 wt Allele