PPP3CA wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PPP3CA wild-type allele is located within 4q21-q24 and is approximately 324 kb in length. This allele, which encodes serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform protein, is involved in calcium-dependent, calmodulin-stimulated protein dephosphorylation. The PPP3CA gene is associated with susceptibility to cardiac hypertrophy.

**Synonyms:** - CALN - CALNA - CALNA1 - CCN1 - CNA - CNA1 - PPP2B - Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform (Calcineurin A Alpha) wt Allele