CDKN1C wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CDKN1C wild-type allele located in the vicinity of 11p15.5 and is approximately 2 kb in length. This allele, which encodes cyclin-dependent kinase inhibitor 1C protein, plays a negative role in the regulation of cellular proliferation by inhibiting several G1 cyclin/Cdk complexes. Mutations of the gene, which generates variant alleles have been implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, suggesting that it is a tumor suppressor candidate.

**Synonyms:** - BWCR - BWS - Cyclin Dependent Kinase Inhibitor 1C wt Allele - Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) Gene - Cyclin-Dependent Kinase Inhibitor 1C Gene - KIP2 - KIP2 Gene - P57-Kip2 Gene - WBS - p57 - p57(KIP2) - p57Kip2