CDKN2A wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CDKN2A wild-type allele is located in the vicinity of 9p21 and is approximately 27 kb in length. This allele, which encodes both cyclin-dependent kinase inhibitor 2A protein and and tumor suppressor ARF protein, is involved in cell cycle regulation at the G1 phase. The allele is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

**Synonyms:** - ARF - CDK2NA - CDK4I - CDKN2 - CDKN2 Gene - CDKN2A-p14ARF - CDKN2A-p16(INK4a) - CMM2 - Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, p16, Inhibits CDK4) Gene - Cyclin-Dependent Kinase Inhibitor 2A wt Allele - INK4 - INK4A - MLM - MTS-1 - MTS1 - P14 - P16 - P16-INK4A - P16INK4 - P19 - P19ARF - TP16 - TSG9A - p14ARF - p16INK4a