PTPN22 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PTPN22 wild-type allele is located within 1p13.3-p13.1 and is approximately 123 kb in length. This allele, which encodes tyrosine-protein phosphatase non-receptor type 22 protein, plays a role in the dephosphorylation of protein-tyrosine phosphates. Functional PTPN22 gene polymorphisms are associated with susceptibility to insulin-dependent diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, and Hashimoto thyroiditis.

**Synonyms:** - LYP - Lyp1 - Lyp2 - Protein Tyrosine Phosphatase, Non-Receptor Type 22 (Lymphoid) wt Allele