CCNE1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CCNE1 wild-type allele is located within 19q12 and is approximately 12 kb in length. This allele, which encodes G1/S-specific cyclin-E1 protein, is involved in the regulation of the G1/S transition of the cell cycle. Variant allelic overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

**Synonyms:** - CCNE - CGE1 - Cyclin E1 wt Allele