CASP10 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CASP10 wild-type allele is located within 2q33-q34 and is approximately 46 kb in length. This allele, which encodes caspase-10 protein, plays a role in the activation of caspase-dependent apoptosis. Defects in the CASP10 gene are the cause of type II autoimmune lymphoproliferative syndrome.

**Synonyms:** - ALPS2 - Apoptotic Protease MCH-4 Gene - Caspase 10 wt Allele - Caspase 10, Apoptosis-Related Cysteine Peptidase Gene - Caspase 10, Apoptosis-Related Cysteine Protease Gene - Caspase-10 Gene - FADD-Like ICE2 Gene - FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2 Gene - FLICE-2 - FLICE2 - Fas-Associated Death Domain Protein Gene - ICE-Like Apoptotic Protease 4 Gene - Interleukin-1B-Converting Enzyme 2 Gene - MCH4