CASP1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CASP1 wild-type allele is located within 11q23 and is approximately 76 kb in length. This allele, which encodes caspase-1 protein, is involved in the cleavage of IL-1 beta releasing the active form of this cytokine. Loss of CASP1 gene expression is associated with prostate cancer.

**Synonyms:** - CASP-1 - Caspase 1, Apoptosis-Related Cysteine Protease wt Allele - Caspase-1 Gene - ICE - IL-1 Beta Converting Enzyme Gene - IL-1BC - IL1B-Convertase Gene - IL1BC - IL1BCE - Interleukin 1-B Converting Enzyme Gene - Interleukin 1-Beta Convertase Gene - Interleukin-1 Beta Converting Enzyme Gene - P45 Gene