CASP7 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CASP7 wild-type allele is located within 10q25 and is approximately 52 kb in length. This allele, which encodes caspase-7 protein, is involved in apoptosis via the cleavage and activation of both sterol regulatory element binding proteins and poly (ADP-ribose) polymerase (PARP). Overexpression of the CASP7 gene promotes programmed cell death. Loss of heterozygosity of the CASP7 gene has been detected in several types of solid tumors.

**Synonyms:** - Apoptotic Protease MCH-3 Gene - CMH-1 - Caspase 7 Gene - Caspase 7, Apoptosis-Related Cysteine Protease wt Allele - Caspase-7 Gene - ICE-LAP3 Gene - ICE-Like Apoptotic Protease 3 Gene - MCH3