CASP8 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CASP8 wild-type allele is located within 2q33-q34 and is approximately 54 kb in length. This allele, which encodes caspase-8 protein, plays a role in apoptosis via the cleavage and activation of caspases 3, 4, 6, 7, 9 and 10. Certain allelic variants of CASP8 are associated with caspase-8 protein deficiency and somatic hepatocellular carcinoma.

**Synonyms:** - Apoptotic Cysteine Protease Gene - Apoptotic Protease MCH-5 Gene - CAP4 - Casp-8 - Caspase 8 wt Allele - Caspase 8, Apoptosis Related Cysteine Protease Gene - Caspase 8, Apoptosis-Related Cysteine Protease Gene - Caspase-8 Gene - FADD-Homologous ICE/CED3-Like Protease Gene - FADD-Like ICE Gene - FLICE - ICE-Like Apoptotic Protease 5 Gene - MACH - MACH-Alpha-1/2/3 Protein Gene - MACH-Beta-1/2/3/4 Protein Gene - MCH5 - MCH5 Isoform Alpha Gene - MORT1-Associated CED-3 Homolog Gene - MORT1-Associated CED3 Homolog Gene