TOP3A wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TOP3A wild-type allele is located within 17p12-p11.2 and is approximately 41 kb in length. This allele, which encodes DNA topoisomerase 3-alpha protein, is involved in the ATP-independent breakage of negatively supercoiled single-stranded DNA and subsequent passage/rejoining of the broken DNA.

**Synonyms:** - TOP3 - Topoisomerase (DNA) III Alpha wt Allele