TOP3B wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TOP3B wild-type allele is located in the vicinity of 22q11.22 and is approximately 26 kb in length. This allele, which encodes DNA topoisomerase 3-beta-1 protein, is involved in the ATP-independent breakage of negatively supercoiled single-stranded DNA and subsequent passage/rejoining of the broken DNA.

**Synonyms:** - Topoisomerase (DNA) III Beta 180kDa wt Allele