Flutamide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)

**Synonyms:** - 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide - 4'-Nitro-3'-trifluoromethylisobutyranilide - 4'-Nitro-3'-trifluoromethylisobutyranilide - Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide - Apimid - Cebatrol - Chimax - Cytomid - Drogenil - Euflex - Eulexin - Eulexine - FLUT - FLUTAMIDE - Flucinom - Flucinome - Flugerel - Fluken - Flulem - Fluta-Gry - Flutabene - Flutacan - Flutamex - Flutamin - Flutan - Flutaplex - Fugerel - Grisetin - Niftolide - Oncosal - Profamid - Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)- - Prostacur - Prostadirex - Prostica - Prostogenat - SCH 13521 - Sch 13521 - Tafenil - Tecnoflut - Testotard - flutamide