SRD5A2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SRD5A2 wild-type allele is located within 2p23 and is approximately 56 kb in length. This allele, which encodes 3-oxo-5-alpha-steroid 4-dehydrogenase 2 protein, plays a role in the oxidation of androgens into their corresponding 5-alpha-3-oxosteroids. Specific heritable defects in the SRD5A2 gene are the cause of pseudovaginal perineoscrotal hypospadias. A specific allelic variant of this gene is associated with an increased risk of prostate cancer.

**Synonyms:** - Steroid-5-Alpha-Reductase, Alpha Polypeptide 2 (3-oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 2) wt Allele