TPO wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TPO wild-type allele is located within 2p25 and is approximately 129 kb in length. This allele, which encodes thyroid peroxidase protein, plays a role in biosynthesis of thyroxine and triiodothyronine. Heritable polymorphisms in the TPO gene commonly result in total iodine organification defect which, in turn, causes severe congenital hypothyroidism.

**Synonyms:** - MSA - TDH2A - TPX - Thyroid Peroxidase wt Allele