ERCC2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human ERCC2 wild-type allele is located in the vicinity of 19q13.3 and is approximately 19 kb in length. This allele, which encodes general transcription and DNA repair factor IIH helicase subunit XPD protein, is involved in transcription-coupled nucleotide excision repair. Defects in this allele can result in three different disorders, xeroderma pigmentosum complementation group D, trichothiodystrophy and Cockayne syndrome.

**Synonyms:** - COFS2 - CXPD - DNA Repair Defect EM9 of Chinese Hamster Ovary Cells, Complementation of Gene - EM9 - ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit wt Allele - ERCC2 - Excision Repair Cross-Complementation Group 2 Gene - Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (Xeroderma Pigmentosum D) Gene - Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 Gene - Excision-Repair, Complementing Defective, In Chinese Hamster, 2 Gene - MAG - MGC102762 - MGC126218 - MGC126219 - TTD - TTD1 - XP, Group D - XP4 - XPD - XPD Gene - XPDC - Xeroderma Pigmentosum Complementary Group D Gene