LIG4 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LIG4 wild-type allele is located within 13q33-q34 and is approximately 11 kb in length. This allele, which encodes DNA ligase 4 protein, is involved in nonhomologous DNA end joining and in V(D)J recombination. Defects in the gene produce allelic variants that are the cause of LIG4 syndrome.

**Synonyms:** - DNA Ligase 4 wt Allele - DNA Ligase IV Gene - LIG4S - Ligase IV, DNA, ATP-Dependent Gene