MLH1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human MLH1 wild-type allele is located in the vicinity of 3p21.3 and is approximately 57 kb in length. This allele, which encodes DNA mismatch repair protein Mlh1, plays a role in DNA mismatch repair. Aberrant alleles are associated with colon, endometrial and stomach cancers. Further, the defects in MLH1 are a cause of hereditary non-polyposis colorectal cancer.

**Synonyms:** - COCA2 - FCC2 - HNPCC2 - MGC5172 - MutL (E. Coli) Homolog 1 (Colon Cancer, Nonpolyposis Type 2) Gene - MutL Homolog 1 wt Allele - MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. coli) Gene - MutL, E. coli, Homolog of, 1 Gene - hMLH1