TREX1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TREX1 wild-type allele is located in the vicinity of 3p21.31 and is approximately 3 kb in length. This allele, which encodes three prime repair exonuclease 1 protein, plays a role in DNA repair. Mutation of the gene is associated with Aicardi-Goutieres syndrome 1, Chilblain lupus, vasculopathy, retinal, with cerebral leukodystrophy, and increased susceptibility to systemic lupus erythematosus.

**Synonyms:** - 3 Prime Repair Exonuclease 1 Gene - 3-Prime Repair Exonuclease 1 Gene - AGS1 - Aicardi-Goutieres Syndrome 1 Gene - CRV - DNase III Gene - DRN3 - Deoxyribonuclease III, DnaQ/MutD (E. coli)-Like Gene - HERNS - Three Prime Repair Exonuclease 1 wt Allele