GSTT1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human GSTT1 wild-type allele is located in the vicinity of 22q11.23 and is approximately 8 kb in length. This allele, which encodes glutathione S-transferase theta-1 protein, is involved in the conjugation of reduced glutathione with both endogenous and exogenous hydrophobic electrophilic compounds. The GSTT1 null genotype is associated with an increased risk for the development of cancer.

**Synonyms:** - Glutathione S-Transferase Theta 1 wt Allele