LCK wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LCK wild-type allele is located in the vicinity of 1p34.3 and is approximately 35 kb in length. This allele, which encodes proto-oncogene tyrosine-protein kinase LCK protein, plays a role in T-cell antigen receptor-linked signal transduction pathways. The LCK gene is associated with acute lymphoblastic leukemia and severe combined immunodeficiency.

**Synonyms:** - IMD22 - LCK Proto-Oncogene, Src Family Tyrosine Kinase wt Allele - LSK - Lymphocyte-Specific Protein Tyrosine Kinase Gene - YT16 - p56lck - pp58lck