LYN wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LYN wild-type allele is located within 8q13 and is approximately 132 kb in length. This allele, which encodes tyrosine-protein kinase Lyn protein, plays a role in B-cell receptor signaling, Fc epsilon receptor I signaling and glycoprotein VI-mediated platelet activation. Decreased expression of the LYN gene is associated with systemic lupus erythematosus.

**Synonyms:** - JTK8 - LYN Proto-Oncogene, Src Family Tyrosine Kinase wt Allele - p53Lyn - p56Lyn - v-YES-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog Gene