AKT1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human AKT1 wild-type allele is located in the vicinity of 14q32.32 and is approximately 26 kb in length. This allele, which encodes RAC-alpha serine/threonine-protein kinase protein, plays a role in mediating the effects of various growth factors and is involved in the transduction of anti-apoptotic and proliferation signals in T-cells. Inherited defects in the AKT1 gene that result in deficiency of its protein product confer susceptibility to schizophrenia.

**Synonyms:** - AKT Serine/Threonine Kinase 1 wt Allele - PKB - PKB-ALPHA - PRKBA - RAC - RAC-ALPHA - RAC-ALPHA Gene - RAC-PK-Alpha - v-akt Murine Thymoma Viral Oncogene Homolog 1 Gene