AKT3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human AKT3 wild-type allele is located within 1q43-q44 and is approximately 355 kb in length. This allele, which encodes RAC-gamma serine/threonine-protein kinase protein, plays a role in the regulation of cell signaling in response to insulin and growth factors. AKT3 gene amplification and overexpression are associated with progression of malignant melanoma.

**Synonyms:** - AKT Serine/Threonine Kinase 3 wt Allele - DKFZP434N0250 - MPPH - MPPH2 - PKB-GAMMA - PKBG - PRKBG - RAC-GAMMA - RAC-PK-Gamma - STK-2 - v-akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) Gene