BRAF wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human BRAF wild-type allele is located within 7q34 and is approximately 190 kb in length. This allele, which encodes B-Raf proto-oncogene serine/threonine-protein kinase protein, plays a role in the transduction of mitogenic signals from the cell membrane to the nucleus. A specific activating somatic mutation in the BRAF gene is associated with several types of cancer such as colorectal and thyroid carcinomas and malignant melanoma.

**Synonyms:** - B-RAF1 - B-Raf Proto-Oncogene Serine/Threonine-Protein Kinase (P94) Gene - B-Raf Proto-Oncogene, Serine/Threonine Kinase wt Allele - B-raf-1 - BRAF1 - Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1 Gene - NS7 - RAFB1 - v-Raf Murine Sarcoma Viral Oncogene Homolog B Gene - v-raf Murine Sarcoma Viral Oncogene Homolog B1 Gene