CHEK1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CHEK1 wild-type allele is located within 11q24-q24 and is approximately 29 kb in length. This allele, which encodes serine/threonine-protein kinase Chk1 protein, plays a role in the induction of cell cycle arrest at the G2/M checkpoint in response to either DNA damage or the presence of unreplicated DNA.

**Synonyms:** - CHK1 - CHK1 (Checkpoint, S. pombe) Homolog Gene - CHK1 Checkpoint Homolog (S. pombe) Gene - Cell Cycle Checkpoint Kinase Gene - Checkpoint Kinase 1 wt Allele - Checkpoint, S. pombe, Homolog of Gene - Serine/Threonine-Protein Kinase CHK1 Gene