PLK3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PLK3 wild-type allele is located in the vicinity of 1p34.1 and is approximately 6 kb in length. This allele, which encodes serine/threonine-protein kinase PLK3 protein, plays a role in the regulation of M phase functions during the cell cycle. The PLK3 gene is down-regulated in certain types of cancer (head and neck squamous cell carcinomas, lung carcinomas) and overexpressed in other types of cancer (breast carcinomas and highly-proliferating malignant epithelial ovarian tumors).

**Synonyms:** - CNK - Cytokine-Inducible Kinase Gene - FNK - PRK - Polo-Like Kinase 3 (Drosophila) wt Allele