LATS1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LATS1 wild-type allele is located within 6q24-q25.1 and is approximately 108 kb in length. This allele, which encodes serine/threonine-protein kinase LATS1 protein, plays a role in cell cycle regulation and cytokinesis. Down-regulation of LATS1 gene expression by promoter hypermethylation is associated with an aggressive phenotype in breast cancer.

**Synonyms:** - LATS (Large Tumor Suppressor, Drosophila) Homolog 1 Gene - LATS, Large Tumor Suppressor, Drosophila, Homolog of, 1 Gene - LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) Gene - LATS, Large Tumor Suppressor, Homolog 1 Gene - Large Tumor Suppressor Kinase 1 wt Allele - WARTS - WTS - wts