LATS2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LATS2 wild-type allele is located within 13q11-q12 and is approximately 87 kb in length. This allele, which encodes serine/threonine-protein kinase LATS2 protein, is involved in centrosome duplication and the maintenance of mitotic fidelity. Down-regulation of LATS1 gene expression by promoter hypermethylation is associated with an aggressive phenotype in breast cancer.

**Synonyms:** - KPM - Kinase Phosphorylated During Mitosis Gene - LATS (Large Tumor Suppressor, Drosophila) Homolog 2 Gene - LATS, Large Tumor Suppressor, Drosophila, Homolog of, 2 Gene - LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) Gene - LATS, Large Tumor Suppressor, Homolog 2 Gene - Large Tumor Suppressor Kinase 2 wt Allele