MAP3K8 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human MAP3K8 wild-type allele is located in the vicinity of 10p11.23 and is approximately 28 kb in length. This allele, which encodes mitogen-activated protein kinase kinase kinase 8 protein, is pleiotropic due to its role in several signaling pathways that are involved in processes such as cell cycle regulation and T-cell activation.

**Synonyms:** - AURA2 - Augmented in Rheumatoid Arthritis 2 Gene - COT - COT (Cancer Osaka Thyroid) Oncogene - COT Gene - Cancer Osaka Thyroid Gene - Cancer Osaka Thyroid Oncogene - EST - ESTF - Ewing Sarcoma Transformant Gene - MEKK8 - Mitogen-Activated Protein Kinase Kinase Kinase 8 wt Allele - Oncogene COT Gene - Proto-Oncogene Serine/Threoine Protein Kinase Gene - TPL-2 - TPL2 - Tpl2 - Tumor Progression Locus 2 Gene - Tumor Progression Locus-2 Gene - c-COT