F8 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human F8 wild-type allele is located within Xq28 and is approximately 548 kb in length. This allele, which encodes coagulation factor VIII protein, is involved in the intrinsic blood coagulation pathway. Defects in this gene generate variant alleles. These variants result in hemophilia A, a common recessive X-linked coagulation disorder.

**Synonyms:** - AHF - Coagulation Factor VIII, Procoagulant Component (Hemophilia A) wt Allele - DXS1253E - F8B - F8C - FVIII - HEMA