EWSR1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human EWSR1 wild-type allele is located in the vicinity of 22q12.2 and is approximately 32 kb in length. This allele, which encodes RNA-binding protein EWS, may play a role in transcriptional repression or post-translational modification. An exact function has not been elucidated; however, mutations of the gene are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. The most common aberration that has been identified is a t(11;22)(q24;q12) translocation.

**Synonyms:** - AC002059.7 - EWS - EWS RNA-Binding Protein 1 wt Allele - Ewing Sarcoma Breakpoint Region 1 Gene - bK984G1.4